| 2009-now |
| “A Transatlantic Think Tank of Toxicology (t4)”
Center for Alternatives to Animal Testing (CAAT) and Center for Alternatives to Animal Testing (CAAT) - Europe
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| 2013-2015 |
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Development of a comprehensive test battery for neuroteratogenicity
Marcel Leist |
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| 2011-2014 |
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Human dopaminergic neurons (LUHMES cells) as substitute for transgenic animal models in neurodegenerative disease and as platform to map pathways of toxicity
Marcel Leist and Stefan Schildknecht
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| 2012-2014 |
| First in vitro approaches to address repeat dose - long-term toxicity
Marcel Leist |
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| 2012-2013 |
| Virtual Pharmacology Lab - a repository of free educational resources to support animal-free pharmacology teaching
David Dewhurst |
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| 2012-2013 |
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Identification of biomarkers for human neurodevelopmental nanotoxicity (Nano-DNT) in a hESC-derived in vitro model
Suzanne Kadereit and Marcel Leist
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| 2011-2012 |
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Development of a high-throughput in vitro system to test the carcinogenic potential of chemicals
Pablo Steinberg
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2009-2012 |
| Modeling of pathways of developmental neurotoxicity as pilot of a
paradigm shift for regulatory safety assessments of chemicals -creation
of the ReTox-21c Centre-
Thomas Hartung |
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| 2010 |
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Replacing animal use in teaching in Eastern European Universities
David Dewhurst and Zvezdana Kojic
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| 2009-2011 |
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Pierre Cosson
Production of recombinant antibodies |
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| 2009-2011 |
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Stefan Schildknecht
Establihtshment and valdation of an improved in vitro model of the blood brain barrier |
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| 2009-2011 |
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Suzanne Kadereit
Development of in vitro embrionic stem cell-based cell assays to screen for toxicity of emerging nanomaterials |
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| 2009-2011 |
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Coenraad F.M. Hendriksen
Development of in vitro quality control tests to replace animal based potency tests for diphtheria and tetanus toxoid vaccines |
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| 2009-2010 |
| Development of an in
vitro method for the determination of tetanus toxicity in tetanus vaccines Karin Weisser and Beate Krämer |
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| 2008 |
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David Dewhurst and Zvezdana Kojic
Replacing animal use in teaching in Eastern European universities |
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| 2008-2010 |
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Marcel Leist and Stefan Schildknecht
Human dopaminergic neurons as substitute for animal models of Parkinson’s disease and for transgenic models with modified expression of PARK genes
Short title: Replacement of animal experiments in Parkinson’s research
DZ chair on alternatives, University of Konstanz, Germany |
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2008-
2010 |
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Marcel Leist and Suzanne Kadereit
In vitro cell differentiation assays to replace rodent and
companion animal use in tests of neurotoxicity and embryotoxicity
DZ chair on alternatives, University of Konstanz, Germany |
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2007-
2008 |
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Troy Seidle
Analysis of current reproductive toxicity assessments to reduce animal use.
Troy Seidle, Kitchener, Ontario, Canada, will do this work during two years at ECVAM, Ispra, Italy |
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| 2007 |
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Barbara M. Rothen-Rutishauser
Use of a particle exposure system to investigate the inflammation and toxicity of nanoparticles in an epithelial airway barrier model.
Institute of Anatomy, Division of Histology, University of Bern, Switzerland |
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| 2007 |
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Michaela Zorn-Kruppa and Heike Scholz
Cytokine secretion profiles of immortalized human corneal cells and three-dimensional human corneal constructs.
Animal Welfare Academy (German Animal Welfare Federation), Neubiberg, Germany |
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| 2007 |
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I-CARE
First National Congress on Alternatives in India, 29-31 January 2007 |
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| 2007 |
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InterNICHE
Outreach and resources to catalyse widespread replacement in education in Latin America |
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| 2006 |
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ProteoSys AG
Stem cell-based in vitro models as a basis to test efficacies of preclinical phases of anti-neurodegenerative treatments
Continuation of a hitherto existing project furthered by the Foundation SET, Frankfurt, Germany |
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2006-
2008 |
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Angelo Vedani
Validation of virtual test kits for predicting harmful effects triggered by drugs and chemicals.
Biografiklabor 3R, Basel, Switzerland |
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| 2006 |
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InterNICHE
Translation English-Spanish of the book "From Guinea Pig to Computer Mouse" |
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| 2004 |
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Doris Höschele
Investigating Mitochondrial Toxicity of HIV-Nucleoside Reverse Transcriptase Inhibitors in ovo |
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| 2001 |
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C. Ross Ethier
Human Anterior Segment Model for Myocilin Perfusion |
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| 2000 |
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Karim R. Sultan
Implementation of in vitro techniques in courses on laboratory animal science |
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| 2000 |
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Jan van der Valk / David Dewhurst
The European resource centre for alternatives in education (eurca) |
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| 1998 |
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Günter Niemeyer
Effects of changes in blood-glucose level on the function of the mammlain retina in vivo and in vitro |
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| 1996 |
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C. Ross Ethier
Non-Invasive Blood Flow Modelling Studies |
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| 1996 |
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Joachim Seelig
Development of Magnetic Resonance Imaging and Spectroscopy as Non-Invasive Tools for Animal Diagnostics |
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| 1994 |
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Mario Raggenbass
Cellular electrophysiology of mammalian motoneurones: an in vitro approach using brainstem slices of the rat |
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| 1994 |
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Richard T. Robertson
Tissue slice culture model for studies of neural degeneration and regeneration |
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| 1994 |
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Michael Sittinger
In vitro synthesis of vital human tissues using resorbable biocompatible polymer fleeces and perfusion culture systems to replace large animal experiments |
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| 1994 |
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Scott M. Thompson
Hippocampal slice cultures: an in vitro alternative for studying anti-convulsant withdrawal seizures |
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| 1991 |
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Gerard J. Mulder
Flow Cytometer |
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| 1990 |
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Arie Bruinink
Investigation of neurotoxic compounds using serum-free cultures of embryonic chick neuronal retina, brain, RPE and meninges cells |
