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Project Overview

2008
to
2010
  Marcel Leist and Stefan Schildknecht
Human dopaminergic neurons as substitute for animal models of Parkinson’s disease and for transgenic models with modified expression of PARK genes
Short title: Replacement of animal experiments in Parkinson’s research
DZ chair on alternatives, University of Konstanz, Germany
     
2008
to
2010
  Marcel Leist and Suzanne Kadereit
In vitro cell differentiation assays to replace rodent and
companion animal use in tests of neurotoxicity and embryotoxicity
DZ chair on alternatives, University of Konstanz, Germany
     
2007
to
2008
  Troy Seidle
Analysis of current reproductive toxicity assessments to reduce animal use.
Troy Seidle, Kitchener, Ontario, Canada, will do this work during two years at ECVAM, Ispra, Italy
     
2007   Barbara M. Rothen-Rutishauser
Use of a particle exposure system to investigate the inflammation and toxicity of nanoparticles in an epithelial airway barrier model.
Institute of Anatomy, Division of Histology, University of Bern, Switzerland
     
2007   Michaela Zorn-Kruppa and Heike Scholz
Cytokine secretion profiles of immortalized human corneal cells and three-dimensional human corneal constructs. 
Animal Welfare Academy (German Animal Welfare Federation), Neubiberg, Germany
     
2007   I-CARE
First National Congress on Alternatives in India, 29-31 January 2007
     
2007   InterNICHE
Outreach and resources to catalyse widespread replacement in education in Latin America
     
2006   ProteoSys AG
Stem cell-based in vitro models as a basis to test efficacies of preclinical phases of anti-neurodegenerative treatments
Continuation of a hitherto existing project furthered by the Foundation SET, Frankfurt, Germany
     
2006
to
2008
  Angelo Vedani
Validation of virtual test kits for predicting harmful effects triggered by drugs and chemicals.
Biografiklabor 3R, Basel, Switzerland
     
2006   InterNICHE
Translation English-Spanish of the book "From Guinea Pig to Computer Mouse"
     
2004    Doris Höschele
Investigating Mitochondrial Toxicity of HIV-Nucleoside Reverse Transcriptase Inhibitors in ovo
     
2001   C. Ross Ethier
Human Anterior Segment Model for Myocilin Perfusion
     
2000   Karim R. Sultan
Implementation of in vitro techniques in courses on laboratory animal science
     
2000   Jan van der Valk / David Dewhurst
The European resource centre for alternatives in education (eurca)
     
1998   Günter Niemeyer
Effects of changes in blood-glucose level on the function of the mammlain retina in vivo and in vitro
     
1996   C. Ross Ethier
Non-Invasive Blood Flow Modelling Studies
     
1996   Joachim Seelig
Development of Magnetic Resonance Imaging and Spectroscopy as Non-Invasive Tools for Animal Diagnostics
     
1994   Mario Raggenbass
Cellular electrophysiology of mammalian motoneurones: an in vitro approach using brainstem slices of the rat
     
1994   Richard T. Robertson
Tissue slice culture model for studies of neural degeneration and regeneration
     
1994   Michael Sittinger
In vitro synthesis of vital human tissues using resorbable biocompatible polymer fleeces and perfusion culture systems to replace large animal experiments
     
1994   Scott M. Thompson
Hippocampal slice cultures: an in vitro alternative for studying anti-convulsant withdrawal seizures
     
1991   Gerard J. Mulder
Flow Cytometer
     
1990   Arie Bruinink
Investigation of neurotoxic compounds using serum-free cultures of embryonic chick neuronal retina, brain, RPE and meninges cells